Chondroregenerative Potential of Platelet-Rich Fibrin (PRF)-Impregnated Decelulrized Bovine Cartilage Scaffold Implanted Subcutaneously

Highlights: This research compared the hondroregenerative potential between bovine cartilage scaffold with platelet-rich fibrin (BCPRF) and autologous cartilage. The formation of newly-regenerated chondrocyte, thickness type II collagen, rate resorption following subcutaneous implantation were assessed. BCPRF is highly biocompatible can be developed as an alternative to alloplastic porous polyethylene (Medpor) implant material. Abstract: invention implants regenerative comparable continues encouraged due high morbidity donor site related harvesting process. attempted using tissue engineering techniques in form endogenous regeneration by combining decellularized that was implanted subcutaneously. study aimed compare chondroregenerative terms collagen produced, implantation. conducted a pretest-posttest control group design New Zealand white rabbits. Forty-eight experimental samples divided into two groups, then treated respectively. results evaluated after six weeks Thirty-nine evaluated. There significant difference found from both groups (p=0.000), (p=0.000). microscopic images demonstrated superior receiving BCPRF. for differed significantly deposition matrix, well rate.